R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.
HIV-1 is a pathogen that T cell responses fail to control.HIV-1gp120 is the surface viral envelope glycoprotein that interacts with CD4 T iphone xr price calgary cells and mediates entry.HIV-1gp120 has been implicated in immune dysregulatory functions that may limit anti-HIV antigen-specific T cell responses.We hypothesized that in the context of e